张健

来源:湖南师范大学生命科学学院   2013-7-10 16:55:57   浏览:2882

 

 
学习经历
1992年在美国迈阿密大学医学院生物化学及分子生物学系获博士学位。1993年在美国迈阿密大学医学院医学系从事博士后工作。
工作经历
1994年开始,在美国耶鲁大学分子、细胞及发育生物学系先后从事博士后和研究员工作。2000年回国受聘为湖南师范大学生命科学学院教授、博士生导师。2000年8月入选教育部“长江学者奖励计划” 特聘教授,同时获国家杰出青年科学基金资助,2004年入选百千万人才工程国家级人选和享受政府特殊津贴,并受聘为上海“模式生物”E-研究院特约研究员,上海第二医科大学兼职博士生导师。现为湖南省卫生厅厅长、政协湖南省第十届委员会常务委员、九三学社湖南省委副主委、全国青联留学人员联谊会理事、湖南省知识分子联谊会副会长、国家遗传工程小鼠资源库第一届技术委员会委员。
主要从事与人类疾病相关的基因及蛋白的鉴定和功能分析。主持国家863计划、国家“973”计划、国家杰出青年基金、国家自然科学基金、教育部创新团队、教育部重点课题、湖南省教育厅重点项目、湖南省自然科学基金等多项课题等科研项目20余项;申请专利5项,已授权2项;在Nature、PNAS、Nucleic Acids Research等国际杂志上发表SCI论文30余篇;2001年获得湖南省青年科技奖。

代表性论著
1.Yingli Zhong, Jiaolian Zhu, Yan Wang, Jianlin Zhou, Kaiqun Ren, Xiaofeng Ding, Xiang Hu, Jian Zhang*(2009) LIM domain protein TES changes its conformational states in different cellular compartments. Mol Cell Biochem. 320:85-92
2.Xiao-Feng Ding,Chang Luo,JianLin Zhou, Yingli Zhong, Xiang Hu, Fangliang Zhou,Kaiqun Ren,Lu Gan,Ailan He,Jiaolian Zhu,Xiang Gao,and Jian Zhang(2009)The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation, Journal of Cellular Biochemistry, 106(2): 285-95
3.Rushi Liu, Aidong Zhou, Daolong Ren, Wenfeng Zhang ,Liping Yang, Mingjun Liu, Hong Li,Jianlin Zhou,Jian Zhang(2009)Transcription Factor Specificity Protein1 (SP1) and Activating Protein 2alpha Regulate Expression of Human KCTD10 by Binding to Proximal Region of the Promoter,FEBS Letter, 276(4)1114 – 1124
4.Xiaoning Peng, Xiaomin Zeng,Sihua Peng, Defeng Deng, Jian Zhang(2009)The Association Risk of Male Subfertility and Testicular Cancer: A Systematic Review,PLOS One,4(5)e5591
5.Hong Li,Qian Liu,Xiang Hu,Du Feng,Shuanglin Xiang,Zhicheng He,Xingwang Hu,Jianlin Zhou,Xiaofeng Ding,Chang Zhou,Jian Zhang(2009)Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator, Acta Biochim Biophys Sin41(7)535–544
6.He Ailan, Xiao Xiangwen, Ren Daolong, Gan Lu,Ding Xiaofeng, Qiao Xi,Hu Xingwang,Liu Rushi,Zhang Jian,Xiang Shuanglin(2009) Identification of target genes of transcription factor activator protein 2 gamma in breast cancer cells, BMC Cancer, 11(9):279
7.Lu GAN,Dong-xing ZHU,Li-ping YANG,Ru-shi LIU,Feng YAN, Jian ZHANG(2008)Involvement of transcription factor activator protein-2α in doxazosin-induced HeLa cell apoptosis,Acta Pharmacol Sin ; 29 (4): 465–472
8.Xiao-Feng Ding,Chang Luo,Kai-Qun Ren,Jing Zhang,Jian-Lin Zhou,Xiang Hu,Ru-Shi Liu,Yan Wang,Xiang Gao,and Jian Zhang(2008)Characterization and Expression of a Human KCTD1 Gene Containing the BTB Domain, Which Mediates Transcriptional Repression and Homomeric Interactions, DNA AND CELL BIOLOGY,27(5):257-265
9.Yan Wang,Haining Peng,Yingli Zhong,Daiqiang Li,Mi Tang,Xiaofeng Ding,Jian Zhang(2008)Differential gene expression profiling of HER2-overexpressing mammary tumor.Acta Biophys Sin,40(5):365-373
10. Xiaofeng Ding,Changzheng Fan,Jianlin Zhou,Yingli Zhong,Rushi Liu, Kaiqun Ren,Xiang Hu,Chang Luo,Shunyong Xiao,Yeqi Wang,Du Feng and Jian Zhang* (2006) GAS41 interacts with transcription factor AP-2β  and stimulates AP-2β -mediated transactivation. Nucleic Acid Res. 34(9):2570-78.
11. Zhou JL, Fan CZ, Zhong YL, Liu YH, Liu MJ, Zhou AD, Ren KQ, Zhang J*. (2005). Genomic organization, promoter characterization and roles of Sp1 and AP-2 in the basal transcription of mouse PDIP1 gene. FEBS Letters, 579(7):1715-17.
12.Zhou J.L., Ren K.Q., Liu X., Xiong X.W., Hu X.X., Zhang J.* (2005) A novel PDIP1 related protein–KCTD10 that interacts with proliferating cell nuclear antigen and DNA polymerase . BBA,1729:200-203.
13. Zhou JL, Xiong XW, Hu XX, Jiang TS, Zhang J*. (2005)Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen,J. of Exp. Zoology, 303A(3):227-40.
14. ZHOU Jianlin, JIE Yucheng, JIANG Yanbo , ZHONG Yingli, LIU Yunhai and ZHANG Jian*(2005). Development of simple sequence repeats (SSR) markers of ramie and comparison of SSR and inter-SSR marker systems. Progress in Natural Science,15(2): 137-142.
15. Jiang TS, Minunni M, Zhang J, Mascini M(2005)Detection of TP53 mutation using a portable Surface Plasmon Resonance DNA-based Biosensor. Biosensors and Bioelectronics, 20 (10): 1939-1945.
16.Zhang J, Sun Y, Liu Y, Sun Y and Liao DJ(2004) Synergistic effects of androgen and estrogen on the mouse uterus and mammary gland. Oncology Reports,12(4):709-716
17.Zhang J, Brewer S, Huang J, Williams T(2003)Overexpression of transcription factor AP-2 alpha suppresses mammary gland growth and morphogenesis. Developmental Biology, 256(1):128-146
18.Zhang J and Williams T(2003)Identification and regulation of tissue-specific cis-acting elements associated with the human AP-2 gene. Developmental Dynamics, 228(2): 194-207.
19.Anand S, Wang WC, Powell DR, Bolanowski SA, Zhang J, Pawashe CL, Amemiya CT and Shashikant CS. (2003) Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes. Proc.Natl.Acad.Sci.USA 100: 15666-15669.


 

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