陈平

来源:湖南师范大学生命科学学院   2013-7-10 17:26:06   浏览:4048

 

陈平 二级教授,生物化学博士。 196211月生,1983年毕业于湖南大学化学化工学院分析化学专业,1988年获湖南师范大学生命科学学院生物化学与分子生物学硕士学位,2005年获生物化学与分子生物学博士学位。2001年曾作为访问学者在美国佛罗里达大学分子细胞生物化学系作访问研究。近年来主要从事蛋白质化学与蛋白质组学的研究。主持了国家973项目子课题“膜蛋白以及膜蛋白复合体的分离鉴定新方法新技术”、国家973前期项目“与血管生成启动相关的质膜蛋白质组研究”、国家自然科学基金项目“肝脏再生过程中血窦内皮细胞功能蛋白质分析”、“肝再生过程中质膜微区蛋白质及复合物动态变化研究”、“肝再生过程中肝血窦内皮细胞动态调控的信号途径及机制研究”、“多肽探针研究Nav1.7调节前列腺癌PC3细胞转移的分子机制,以及湖南省科技厅重点项目“细胞膜蛋白质组研究方法发展及其在神经系统细胞质膜蛋白质组研究中的应用”的研究;并作为主要骨干研究人员参与并完成了国家科技攻关计划“人类健康肝脏蛋白质组表达谱以及国家973项目“重要疾病的蛋白质组学研究”等研究工作;曾获2007年及2003年湖南省科技厅科技进步奖一等奖和1999年国家教育部科技进步奖三等奖以及1项国家专利(专利号 为:ZL 2004 1 0023089 X)。在“Journal of Neurochemistry”、“Journal of Proteome Research等杂志上已发表相关论文80余篇,参编著作三部。
 
近五年主持的各类国家科技计划项目情况: 

序号
项目名称及编号
*项目来源
批准时间
经费(万元)
 
1
与血管生成启动相关的质膜蛋白质组研究 (2007CB516809)
国家重点基础研究发展计划(973项目)
 
2007
 
97.28万元
 
2
膜蛋白以及膜蛋白复合体的分离鉴定新方法新技术(2007CB914203)
国家重点基础研究发展计划(973项目)
 
2007
 
331万元
 
3
肝脏再生过程中血窦内皮细胞功能蛋白质分析(30770437
国家自然科学基金项目
 
2007
 
30万元
 
4
肝再生过程中质膜微区蛋白质及复合物动态变化研究81070353
国家自然科学基金项目
 
2010
 
32万元
 
5
多肽探针研究Nav1.7调节前列腺癌PC3细胞转移的分子机制(31370817)
国家自然科学基金项目
 
2013
 
80万元
 
6
肝再生过程中肝血窦内皮细胞动态调控的信号途径及机制研究(31670838)
国家自然科学基金项目
 
2016
 
60万元

近年来以通讯作者或第一作者发表的主要研究论文

1. Jiang M, Qi L, Liu P, Wang Z, Duan Z, Wang Y, Liu Z, Chen P*,. Selective enrichment and desalting of hydrophilic peptides using graphene oxide. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 1; 1027:149-157.

2. Ge L, Jiang M, Duan D, Wang Z, Qi L, Teng X, Zhao Z, Wang L, Zhuo Y, Chen P*, He X, Lu M.  Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell.  Stem Cells Int. 2016:1243659.

3. Yu J, Lin S, Wang M, Liang L, Zou Z, Zhou X, Wang M, Chen P*, Wang Y. Metastasis suppressor 1 regulates neurite outgrowth in primary neuron cultures. Neuroscience. 2016, 333:123-131

4. Cheng Zhang, Jinyan Li, Xinhong Guo, Baode Zhu, Wenjun Xiao, Ping Wang, Miao Jiang, Shuai Hu, Xiutao Lu, Zhuang He, Ping Chen*. LecRK-VII.1, a Lectin Receptor-Like Kinase, Mediates the Regulation of Salt Stress and Jasmonic Acid Response in Arabidopsis. Journal of Plant Growth Regulation. 2016,12

5. Li J, Gao J, Jiang M, Chen J, Liu Z, Chen P*, Liang S. Rat liver sinusoidal surface N-linked glycoproteomic analysis by affinity enrichment and mass spectrometric identification. Biochemistry (Mosc). 2015 Mar;80(3):260-75

6. Zhang W, Long J, Zhang C, Cai N, Liu Z, Wang Y, Wang X, Chen P*, Liang S.  A method combining SPITC and 18O labeling for simultaneous protein identification and relative quantification. J.Mass.Spectrom. 2014,49(5): 400-408

7. Wang L, Jiang M, Duan D, Zhao Z, Ge L, Teng X, Liu B, Liu B, Chen P*, Lu M. Hyperthermia-conditioned OECs serum-free-conditioned medium induce NSC differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity. Transplantation. 2014, 97(12):1225-1232 

8. Rui Cao, Ke Chen, Qin Song, Yi Zang, Jia Li, Xianchun Wang, Ping Chen* and Songping Liang. Quantitative Proteomic Analysis of Membrane Proteins Involved in Astroglial Differentiation of Neural Stem Cells by SILAC Labeling Coupled with LC–MS/MS. J.Proteome Res., 2012, 11 (2)829–838     

9. Shi N, Tian C, Liang X, Jiang P, Liang L, Zhou L, Shu Y. Chen P*Wang Y. Proteome analysis of actin filament a ssociated proteins in the postnatal rat cerebellum. Neuroscience.2012227: 90-101.

10. Chunliang Xie, Nvying Liu, Jia Long, Cheng Tang, Jianglin Li, Linju Huo, Xianchun Wang, Ping Chen*, Songping Liang.  Blue Native/SDS-PAGE Combined with iTRAQ Analysis Reveals Advanced Glycation Endproducts-Induced Changes of Synaptosome Proteins in C57 BL/6 Mice.  Electrophoresis. 2011, 32: 2194–2205   

11. Liu Y, Teng X, Yang X, Song Q, Lu R, Xiong J, Liu B, Zeng N, Zeng Y, Long J, Cao R, Lin Y, He Q, Chen P*, Lu M, Liang S.  Shotgun proteomics and network analysis between plasma membrane and extracellular matrix proteins from rat olfactory ensheathing cells. Cell transplantation.  2010,19(2):133-146.    

12. Cao R, Liu Y, Chen P*, Lv R, Song Q, Sheng T, He Q, Wang Y, Wang X, Liang S. Improvement of hydrophobic integral membrane protein identification by mild performic acid oxidation-assisted digestion.  Anal Biochem. 2010 ,15; 407(2):196-204.

13. Xuanwen Li, Li Xiong, Chunliang Xie, Jia Cao, Huobao Deng, Yong Lin, Rui Cao, Jianglin Li, Ping Chen* , Songping Liang.  Proteomics analysis of plasma membrane from liver sinusoidal endothelial cells after partial hepatectomy by an improved two-dimensional electrophoresis.  Molecular and Cellular Biochemistry  20103441-2): 137-150.  

14. Li Xuanwen, Xie Chunliang, Jin Qihui, Liu Minhjun, He Quanyuan, Cao Rri, Lin Ying, Li Jianglin, Li Yan, Chen Ping*, Liang Songping.  Proteomic Screen for Multiprotein Complexes in Synaptic Plasma Membrane from Rat Hippocampus by Blue Native Gel Electrophoresis and Tandem Mass SpectrometryJournal of Proteome Research200983475-3486  

15. Chen Ping, Zhang Lijun, Li Xuanwen, Wang Xie, Cao Rui, Liu Zhen, Cao Rui, Xiong Jixian, Peng Xia, Wei Yingjuan, Wang Xianchun, and Liang Songping. Evaluation of strategy for analyzing mouse liver plasma membrane proteome. Science in China Series C:Life Sciences. 2007,50(6)731-738                       

16. Chen Ping, Li Xuanwen, Sun Yalan, Liu Zhen, Cao Rui, He Quanyuan, Wang Meichi, Xiong Jixian, Xie Jinyun, Wang Xianchun, and Liang Songping. Proteomic analysis of rat hippocampus plasma membrane: characterization of potential neuronal-specific plasma membrane proteins. Journal Of Neurochemistry. 2006,981126-1140

17. Chen Ping, Nie SongWang Xiangchun, Liang Songping.  De nove sequencing of tryptic peptides sulfonated by 4-sulfophenyl isothiocyanate for unambiguous protein identification using post-source decay matrix-assisted laser desorption/ionization mass spectrometry.  Rapid Commun. Mass Spectrom2004,18:191-198.    

18. 陈平 参编著作CLINICALRESEARCHAND TREATMENT APPROACHES TO AFFECTIVE DISORDERS》(英文), 欧洲INTECH出版社,2012

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