丁小凤

来源:湖南师范大学生命科学学院   2013-7-10 17:54:18   浏览:4101

 

 

姓名:丁小凤
学科:分子生物学
研究方向:基因调控及功能研究
 
学习经历:
 
 
2005.09-2008.06南京大学模式动物研究所遗传学(湖南师范大学生命科学学院联合培养),博士
2002.09-2005.06湖南师范大学生命科学学院生物化学与分子生物学专业,硕士
1998.09-2002.06 湖南师范大学生物系生物科学专业,本科
 
 
工作经历:
 
 
2010年11月至今,副教授,湖南师范大学生命科学学院生物化学与分子生物学系基因功能与调控研究室工作。承担本科生«分子生物学»理论课和实验课及«生物伦理学»教学工作。
2008年9月-2010年10月,讲师,湖南师范大学生命科学学院。
 
 
承担科研课题:
 
 
1.“转录因子AP-2β在宫颈癌发生发展中的作用及机理研究”, 国家自然科学基金面上项目(81272190),2013-2016
2.“MLL相关基因GAS41与AP-2alpha结合在急性白血病发生中的作用和机制”,国家自然科学基金青年项目(30900827),2010-2012
3. “抗白血病转移药物筛选绿色荧光裸鼠模型的建立及应用”, 湖南省科技厅科研条件创新专项,2012-2013
4. “转录因子AP-2β对宫颈癌细胞生物学行为的影响及机制研究”, 湖南省教育厅青年科研项目,2013-2016
 
 
代表性论文:
 
 
1. Xiaofeng Ding1, Zijian Yang1, Fangliang Zhou1, Fangmei Wang, Xinxin Li, Cheng Chen, Xiaofeng Li, Xiang Hu, Shuanglin Xiang*, Jian Zhang*, Transcription factor AP-2α regulates acute myeloid leukemia U937 cell proliferation by influencing Hoxa gene expression, Int J Biochem Cell Biol, 2013, 45:1647-1656 IF: 4.152
2. Xiaofeng Ding1, Fangliang Zhou1, Zijian Yang1, Xiang Hu, Chang Zhou, Jianlin Zhou, Fangmei Wang, Bo Zhang, Guangwei Wang, Chang Luo, Ling Xiao, Shoulian Xiang, Shuanglin Xiang﹡, Jian Zhang﹡,Eps8 regulates cellular growth of human Glioma, Oncology Reports,, 2013, 29: 697-703 IF: 2.297
3. Hu X, Yan F, Wang F, Yang Z, Xiao L, Li L, Xiang S, Zhou J, Ding X﹡ (co-corresponding author), Zhang J﹡, TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1, Mol Biol Rep, 2012, 39:9911-9919. IF: 2.506
4. Xiaofeng Ding#, Zijian Yang#, Fangliang Zhou, Xiang Hu, Chang Zhou, Chang Luo, Zhicheng He, Qian Liu, Hong Li, Feng Yan, Fangmei Wang, Shuanglin Xiang﹡, Jian Zhang﹡, Human Intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation. BMB reports, 2012, 45: 183-188. IF: 1.634
5. Yuan Wu., Yuzhong Xiao., Xiaofeng Ding. (co-first author), Yiming Zhuo, Peng Ren, Chang Zhou*, Jianlin Zhou* A miR-200b/200c/429-Binding Site Polymorphism in the 3’ Untranslated Region of the AP-2a Gene Is Associated with Cisplatin Resistance, PLOS One, 2011,6:1-5 IF: 4.092
6. Xiaofeng Ding 1, 2, Chang Luo 2, Jianlin Zhou 2, Yingli Zhong 2, Xiang Hu 2, Fangliang Zhou 2, Kaiqun Ren 1, 2, Lu Gan 2, Ailan He 2, Jiaolian Zhu 2, Xiang Gao 1 *, Jian Zhang 2*. The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation. Journal of Cellular Biochemistry, 2009, 106:285-295 IF: 3.54
7. Xiao-Feng Ding,1,2 Chang Luo,2 Kai-Qun Ren,1,2 Jing Zhang,3 Jian-Lin Zhou,2 Xiang Hu,2 Ru-Shi Liu,2 Yan Wang,2 Xiang Gao,1* and Jian Zhang2*. Characterization and Expression of a Human KCTD1 Gene Containing the BTB Domain, Which Mediates Transcriptional Repression and Homomeric Interactions. DNA and Cell biology, 2008, 27: 257-265 IF: 1.988
8. Xiaofeng Ding1, Changzheng Fan1, Jianlin Zhou1, Yingli Zhong1, Rushi Liu1, Kaiqun Ren1, Xiang Hu1, Chang Luo1, Shunyong Xiao1, Yeqi Wang1, Du Feng1 and Jian Zhang1,2,*. GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. Nucleic Acids Research. 2006, 34:2570-2578 IF: 7.55

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