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何定庚

发布人:日期:2019-05-09 09:07浏览数:

何定庚 Dinggeng He

湖南师范大学教授,博士生导师

所属学科:微生物学

Tel: 13787169067

E-mail:hedinggeng@hnu.edu.cn; hedgnhm@163.com

通讯地址:湖南长沙岳麓区湖南师范大学生命科学学院, 410081

个人简介:

何定庚,湖南师范大学生命科学学院教授,博士生导师。1985年出生于湖南湘潭。2009年于湖南大学获分析化学硕士学位。2012年获湖南大学分析化学博士学位。2012-2016年湖南大学化学化工学院助理研究员,化学生物传感与计量学国家重点实验室成员。2016-2019年香港浸会大学理学院博士后。2018年7月入职湖南师范大学生命科学学院。曾荣获“芙蓉学者”青年学者(2020年)、香江学者奖(2016年)、湖南省优秀博士学位论文(2014年)等奖励。长期致力于生命分析化学与生物医学领域的前沿研究,在生物功能化纳米材料制备、核酸分子/纳米探针设计、智能诊疗体系构建与应用等方面取得了一系列创新成果,获得国内外同行的认可。近年来,已在Adv. Funct. Mater.Chem. Sci.ACS Appl. Mater. Inter.TheranosticsAnal. Chem.Chem. Commun.等国际知名学术刊物上发表SCI论文90余篇,其中第一/通讯作者论文近40篇(包括IF>15论文2篇、IF>5论文20篇),论文总他引2900余次,h-index为32;主持承担2项国家自然科学基金项目、2项湖南省自然科学基金项目,参与多项国家级和省部级重点项目的研究;受邀担任Frontiers in Chemistry (IF = 4.155),Nanomaterials(IF 4.324)客座编辑、担任Anal Chem、Theranostics等国际期刊审稿人、湖南省微生物学会理事等职务;入选斯坦福大学提供的分析化学领域全球Top 2%科学家名单。


研究兴趣:

1.食源性致病菌及淡水养殖水体中鱼类致病菌的高灵敏、可视化检测;

2.针对肿瘤细胞以及耐药菌的新型诊疗纳米体系设计与活体应用;

3.制备多功能水凝胶伤口敷料和可植入的医用高分子涂层材料用于高效抗菌。

代表性论文(10篇):

1.Dinggeng He,Luo Hai, Xing He, Xue Yang, Hung-Wing Li*.Glutathione-activatable and O2/Mn2+-evolving nanocomposite for highly efficient and selective photodynamic and gene-silencing dual therapy.Advanced Functional Materials2017,27, 1704089 (IF = 16.836)

2.Dinggeng He, Xiaoxiao He, Kemin Wang*, Jie Cao, Yingxiang Zhao.A photon-fueled gate-like delivery system using i-motif DNA functionalized mesoporous silica nanoparticles.Advanced Functional Materials2012,22, 4704-4710. (Highlighted by Wiley-VCH Materials Views China) (IF = 16.836)

3.Dinggeng He, Xing He, Xue Yang, Hung-Wing Li*.A smart ZnO@polydopamine-nucleic acid nanosystem for ultrasensitive live cell mRNA imaging by the target-triggered intracellular self-assembly of active DNAzyme nanostructures.Chemical Science2017, 8, 2832-2840. (IF = 9.346)

4.Ke Yang, Huizhen Wang, Ning Ma, Ming Zeng, Huaiqing Luo,Dinggeng He*(通讯作者).Programmable target-initiated DNAzyme walker walking along a spatially isolated and highly hybridizable substrate track on a nanoparticle surface.ACS Applied Materials & Interfaces2018,10, 44546-44553. (IF = 8.758)

5.Dinggeng He,Huizhen Wang,See-Lok Ho,Hei-Nga Chan,Luo Hai,Xiaoxiao He,Kemin Wang,Hung-Wing Li*. Total internal reflection-based single-vesicle in situ quantitative and stoichiometric analysis of tumor-derived exosomal microRNAs for diagnosis and treatment monitoring.Theranostics2019,9, 4494-4507. (IF =8.579)

6.Dinggeng He, See-Lok Ho, Hei-Nga Chan, Huizhen Wang, Luo Hai, Xiaoxiao He*, Kemin Wang*, Hung-Wing Li*. Molecular-recognition-based DNA nanodevices for enhancing the direct visualization and quantification of single vesicles of tumor exosomes in plasma microsamples.Analytical Chemistry2019,91, 2768-2775. (IF = 6.785)

7.Huizhen Wang, Kejing Wan, Yue Zhou, Xiaoxiao He,*Dinggeng He,*(通讯作者)Hong Cheng, Jin Huang, Ruichen Jia, Kemin Wang. A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes.Chemical Communication,2020, 56, 12949-12952.(IF = 5.996)

8.Dinggeng He, Xiaoxiao Yang, Xiaoxiao He,* Kemin Wang,* Xue Yang, Xing He, Zhen Zou. A sensitive turn-on fluorescent probe for intracellular imaging of glutathione using single-layer MnO2nanosheet-quenched fluorescent carbon quantum dots.Chemical Communication,2015, 51, 14764-14767.(IF = 5.996)

9.Dinggeng He, Xiaoxiao He,* Kemin Wang,* Xue Yang, Xiaoxiao Yang, Zhen Zou, Xuecai Li.Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release.Chemical Communication,2015, 51, 776-779.(IF = 5.996)

10.Dinggeng He, Xiaoxiao He,* Kemin Wang,* Xue Yang, Xiaoxiao Yang, Xuecai Li, Zhen ZouNanometer-sized manganese oxide-quenched fluorescent oligonucleotides: an effective sensing platform for probing biomolecular interactions.Chemical Communication,2014, 50, 11049-11052.(IF = 5.996)

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